The International Testicular Cancer Linkage Consortium: A clinicopathologic descriptive analysis of 461 familial malignant testicular germ cell tumor kindred
Identifieur interne : 007472 ( Main/Exploration ); précédent : 007471; suivant : 007473The International Testicular Cancer Linkage Consortium: A clinicopathologic descriptive analysis of 461 familial malignant testicular germ cell tumor kindred
Auteurs : Phuong L. Mai [États-Unis] ; Michael Friedlander [Australie] ; Kathy Tucker [Australie] ; Kelly-Anne Phillips [Australie] ; David Hogg [Canada] ; Michael A. S. Jewett [Canada] ; Radka Lohynska [République tchèque] ; Gedske Daugaard [Danemark] ; Stéphane Richard [France] ; Catherine Bonaïti-Pellie [France] ; Axel Heidenreich [Allemagne] ; Peter Albers [Allemagne] ; Istvan Bodrogi [Hongrie] ; Lajos Geczi [Hongrie] ; Edith Olah [Hongrie] ; Peter A. Daly [Irlande (pays)] ; Parry Guilford [Nouvelle-Zélande] ; Sophie D. Fossa ; Ketil Heimdal ; Ludmila Liubchenko ; Sergei A. Tjulandin ; Hans Stoll ; Walter Weber ; Douglas F. Easton ; Darshna Dudakia ; Robert Huddart ; Michael R. Stratton ; Lawrence Einhorn ; Larissa Korde [États-Unis] ; Katherine L. Nathanson ; D. Timothy Bishop ; Elizabeth A. Rapley ; Mark H. Greene [États-Unis]Source :
- Urologic oncology [ 1078-1439 ] ; 2010.
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Abstract
Objectives: Familial aggregation of testicular germ cell tumor (TGCT) has been reported, but it is unclear if familial TGCT represents a unique entity with distinct clinicopathologic characteristics. Here we describe a collection of familial TGCT cases from an international consortium, in an effort to elucidate any clinical characteristics that are specific to this population. Materials and methods: Families with ≥2 cases of TGCT enrolled at 18 of the sites participating in the International Testicular Cancer Linkage Consortium were included. We analyzed clinicopathologic characteristics of 985 cases from 461 families. Results: A majority (88.5%) of families had only 2 cases of TGCT. Men with seminoma (50% of cases) had an older mean age at diagnosis than nonseminoma cases (P = 0.001). Among individuals with a history of cryptorchidism, TGCT was more likely to occur in the ipsilateral testis (κ = 0.65). Cousin pairs appeared to represent a unique group, with younger age at diagnosis and a higher prevalence of cryptorchidism than other families. Conclusions: Clinicopathologic characteristics in these familial TGCT cases were similar to those generally described for nonfamilial cases. However, we observed a unique presentation of familial TGCT among cousin pairs. Additional studies are needed to further explore this observation.
Affiliations:
- Allemagne, Australie, Canada, Danemark, France, Hongrie, Irlande (pays), Nouvelle-Zélande, République tchèque, États-Unis
- Bohême centrale, District de Cologne, District de Kassel, Hesse (Land), Hongrie centrale, Hovedstaden, Nouvelle-Galles du Sud, Ontario, Rhénanie-du-Nord-Westphalie
- Budapest, Cassel (Hesse), Cologne, Copenhague, Prague, Sydney, Toronto
- Université de Toronto
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Mai</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute</s1><s2>Rockville, MD 20852</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>29 aut.</sZ><sZ>33 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Rockville, MD 20852</wicri:noRegion></affiliation></author><author><name sortKey="Friedlander, Michael" sort="Friedlander, Michael" uniqKey="Friedlander M" first="Michael" last="Friedlander">Michael Friedlander</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Medical Oncology, Division of Medicine, University of New South Wales and Prince of Wales Hospital Randwick</s1><s2>Sydney</s2><s3>AUS</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Tucker, Kathy" sort="Tucker, Kathy" uniqKey="Tucker K" first="Kathy" last="Tucker">Kathy Tucker</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Medical Oncology, Division of Medicine, University of New South Wales and Prince of Wales Hospital Randwick</s1><s2>Sydney</s2><s3>AUS</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Phillips, Kelly Anne" sort="Phillips, Kelly Anne" uniqKey="Phillips K" first="Kelly-Anne" last="Phillips">Kelly-Anne Phillips</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Haematology and Medical Oncology, Peter MacCallum Cancer Centre</s1><s2>East Melbourne</s2><s3>AUS</s3><sZ>4 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>East Melbourne</wicri:noRegion></affiliation></author><author><name sortKey="Hogg, David" sort="Hogg, David" uniqKey="Hogg D" first="David" last="Hogg">David Hogg</name><affiliation wicri:level="4"><inist:fA14 i1="04"><s1>Princess Margaret Hospital and University of Toronto</s1><s2>Toronto</s2><s3>CAN</s3><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation></author><author><name sortKey="Jewett, Michael A S" sort="Jewett, Michael A S" uniqKey="Jewett M" first="Michael A. 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Daly</name><affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Department of Medical Oncology, St James's Hospital</s1><s2>Dublin</s2><s3>IRL</s3><sZ>16 aut.</sZ></inist:fA14><country>Irlande (pays)</country><wicri:noRegion>Dublin</wicri:noRegion></affiliation></author><author><name sortKey="Guilford, Parry" sort="Guilford, Parry" uniqKey="Guilford P" first="Parry" last="Guilford">Parry Guilford</name><affiliation wicri:level="1"><inist:fA14 i1="13"><s1>Cancer Genetics Laboratory, University of Otago</s1><s2>Dunedin</s2><s3>NZL</s3><sZ>17 aut.</sZ></inist:fA14><country>Nouvelle-Zélande</country><wicri:noRegion>Dunedin</wicri:noRegion></affiliation></author><author><name sortKey="Fossa, Sophie D" sort="Fossa, Sophie D" uniqKey="Fossa S" first="Sophie D." last="Fossa">Sophie D. Fossa</name></author><author><name sortKey="Heimdal, Ketil" sort="Heimdal, Ketil" uniqKey="Heimdal K" first="Ketil" last="Heimdal">Ketil Heimdal</name></author><author><name sortKey="Liubchenko, Ludmila" sort="Liubchenko, Ludmila" uniqKey="Liubchenko L" first="Ludmila" last="Liubchenko">Ludmila Liubchenko</name></author><author><name sortKey="Tjulandin, Sergei A" sort="Tjulandin, Sergei A" uniqKey="Tjulandin S" first="Sergei A." last="Tjulandin">Sergei A. Tjulandin</name></author><author><name sortKey="Stoll, Hans" sort="Stoll, Hans" uniqKey="Stoll H" first="Hans" last="Stoll">Hans Stoll</name></author><author><name sortKey="Weber, Walter" sort="Weber, Walter" uniqKey="Weber W" first="Walter" last="Weber">Walter Weber</name></author><author><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F." last="Easton">Douglas F. Easton</name></author><author><name sortKey="Dudakia, Darshna" sort="Dudakia, Darshna" uniqKey="Dudakia D" first="Darshna" last="Dudakia">Darshna Dudakia</name></author><author><name sortKey="Huddart, Robert" sort="Huddart, Robert" uniqKey="Huddart R" first="Robert" last="Huddart">Robert Huddart</name></author><author><name sortKey="Stratton, Michael R" sort="Stratton, Michael R" uniqKey="Stratton M" first="Michael R." last="Stratton">Michael R. Stratton</name></author><author><name sortKey="Einhorn, Lawrence" sort="Einhorn, Lawrence" uniqKey="Einhorn L" first="Lawrence" last="Einhorn">Lawrence Einhorn</name></author><author><name sortKey="Korde, Larissa" sort="Korde, Larissa" uniqKey="Korde L" first="Larissa" last="Korde">Larissa Korde</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute</s1><s2>Rockville, MD 20852</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>29 aut.</sZ><sZ>33 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Rockville, MD 20852</wicri:noRegion></affiliation></author><author><name sortKey="Nathanson, Katherine L" sort="Nathanson, Katherine L" uniqKey="Nathanson K" first="Katherine L." last="Nathanson">Katherine L. Nathanson</name></author><author><name sortKey="Bishop, D Timothy" sort="Bishop, D Timothy" uniqKey="Bishop D" first="D. Timothy" last="Bishop">D. Timothy Bishop</name></author><author><name sortKey="Rapley, Elizabeth A" sort="Rapley, Elizabeth A" uniqKey="Rapley E" first="Elizabeth A." last="Rapley">Elizabeth A. Rapley</name></author><author><name sortKey="Greene, Mark H" sort="Greene, Mark H" uniqKey="Greene M" first="Mark H." last="Greene">Mark H. Greene</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute</s1><s2>Rockville, MD 20852</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>29 aut.</sZ><sZ>33 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Rockville, MD 20852</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">10-0472855</idno><date when="2010">2010</date><idno type="stanalyst">PASCAL 10-0472855 INIST</idno><idno type="RBID">Pascal:10-0472855</idno><idno type="wicri:Area/PascalFrancis/Corpus">002305</idno><idno type="wicri:Area/PascalFrancis/Curation">003C89</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">001F56</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">001F56</idno><idno type="wicri:doubleKey">1078-1439:2010:Mai P:the:international:testicular</idno><idno type="wicri:Area/Main/Merge">007A24</idno><idno type="wicri:Area/Main/Curation">007472</idno><idno type="wicri:Area/Main/Exploration">007472</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">The International Testicular Cancer Linkage Consortium: A clinicopathologic descriptive analysis of 461 familial malignant testicular germ cell tumor kindred</title><author><name sortKey="Mai, Phuong L" sort="Mai, Phuong L" uniqKey="Mai P" first="Phuong L." last="Mai">Phuong L. Mai</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute</s1><s2>Rockville, MD 20852</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>29 aut.</sZ><sZ>33 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Rockville, MD 20852</wicri:noRegion></affiliation></author><author><name sortKey="Friedlander, Michael" sort="Friedlander, Michael" uniqKey="Friedlander M" first="Michael" last="Friedlander">Michael Friedlander</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Medical Oncology, Division of Medicine, University of New South Wales and Prince of Wales Hospital Randwick</s1><s2>Sydney</s2><s3>AUS</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Tucker, Kathy" sort="Tucker, Kathy" uniqKey="Tucker K" first="Kathy" last="Tucker">Kathy Tucker</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Medical Oncology, Division of Medicine, University of New South Wales and Prince of Wales Hospital Randwick</s1><s2>Sydney</s2><s3>AUS</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Phillips, Kelly Anne" sort="Phillips, Kelly Anne" uniqKey="Phillips K" first="Kelly-Anne" last="Phillips">Kelly-Anne Phillips</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Haematology and Medical Oncology, Peter MacCallum Cancer Centre</s1><s2>East Melbourne</s2><s3>AUS</s3><sZ>4 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>East Melbourne</wicri:noRegion></affiliation></author><author><name sortKey="Hogg, David" sort="Hogg, David" uniqKey="Hogg D" first="David" last="Hogg">David Hogg</name><affiliation wicri:level="4"><inist:fA14 i1="04"><s1>Princess Margaret Hospital and University of Toronto</s1><s2>Toronto</s2><s3>CAN</s3><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation></author><author><name sortKey="Jewett, Michael A S" sort="Jewett, Michael A S" uniqKey="Jewett M" first="Michael A. S." last="Jewett">Michael A. S. Jewett</name><affiliation wicri:level="4"><inist:fA14 i1="04"><s1>Princess Margaret Hospital and University of Toronto</s1><s2>Toronto</s2><s3>CAN</s3><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation></author><author><name sortKey="Lohynska, Radka" sort="Lohynska, Radka" uniqKey="Lohynska R" first="Radka" last="Lohynska">Radka Lohynska</name><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>University Hospital, Department of Radiotherapy and Oncology</s1><s2>Prague</s2><s3>CZE</s3><sZ>7 aut.</sZ></inist:fA14><country>République tchèque</country><placeName><settlement type="city">Prague</settlement><region type="région" nuts="2">Bohême centrale</region></placeName></affiliation></author><author><name sortKey="Daugaard, Gedske" sort="Daugaard, Gedske" uniqKey="Daugaard G" first="Gedske" last="Daugaard">Gedske Daugaard</name><affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Department of Oncology, Rigshospitalet</s1><s2>Copenhagen</s2><s3>DNK</s3><sZ>8 aut.</sZ></inist:fA14><country>Danemark</country><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="Richard, Stephane" sort="Richard, Stephane" uniqKey="Richard S" first="Stéphane" last="Richard">Stéphane Richard</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Génétique Oncologique EPHE-CNRS FRE 2939 Faculté de Médecine Paris-Sud; Service d'Urologie, CHU, Le Kremlin-Bicêtre; Institut Gustave Roussy</s1><s2>Villejuif</s2><s3>FRA</s3><sZ>9 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Le Kremlin-Bicêtre; Institut Gustave Roussy</wicri:noRegion><wicri:noRegion>Villejuif</wicri:noRegion></affiliation></author><author><name sortKey="Bonaiti Pellie, Catherine" sort="Bonaiti Pellie, Catherine" uniqKey="Bonaiti Pellie C" first="Catherine" last="Bonaïti-Pellie">Catherine Bonaïti-Pellie</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>INSERM U 535, Villejuif, F-94817 France; Univ Paris-Sud</s1><s2>Villejuif</s2><s3>FRA</s3><sZ>10 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>94817 France; Univ Paris-Sud</wicri:noRegion><wicri:noRegion>Villejuif</wicri:noRegion></affiliation></author><author><name sortKey="Heidenreich, Axel" sort="Heidenreich, Axel" uniqKey="Heidenreich A" first="Axel" last="Heidenreich">Axel Heidenreich</name><affiliation wicri:level="3"><inist:fA14 i1="09"><s1>Department of Urology, Division of Oncological Urology, University of Köln</s1><s2>Köln</s2><s3>DEU</s3><sZ>11 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Cologne</settlement></placeName></affiliation></author><author><name sortKey="Albers, Peter" sort="Albers, Peter" uniqKey="Albers P" first="Peter" last="Albers">Peter Albers</name><affiliation wicri:level="3"><inist:fA14 i1="10"><s1>Department of Urology, Klinikum Kassel GmbH</s1><s2>Kassel</s2><s3>DEU</s3><sZ>12 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Kassel</region><settlement type="city">Cassel (Hesse)</settlement></placeName></affiliation></author><author><name sortKey="Bodrogi, Istvan" sort="Bodrogi, Istvan" uniqKey="Bodrogi I" first="Istvan" last="Bodrogi">Istvan Bodrogi</name><affiliation wicri:level="3"><inist:fA14 i1="11"><s1>Department of Molecular Genetics and Department of Chemotherapy, National Institute of Oncology</s1><s2>Budapest</s2><s3>HUN</s3><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Hongrie</country><placeName><settlement type="city">Budapest</settlement><region nuts="2">Hongrie centrale</region></placeName></affiliation></author><author><name sortKey="Geczi, Lajos" sort="Geczi, Lajos" uniqKey="Geczi L" first="Lajos" last="Geczi">Lajos Geczi</name><affiliation wicri:level="3"><inist:fA14 i1="11"><s1>Department of Molecular Genetics and Department of Chemotherapy, National Institute of Oncology</s1><s2>Budapest</s2><s3>HUN</s3><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Hongrie</country><placeName><settlement type="city">Budapest</settlement><region nuts="2">Hongrie centrale</region></placeName></affiliation></author><author><name sortKey="Olah, Edith" sort="Olah, Edith" uniqKey="Olah E" first="Edith" last="Olah">Edith Olah</name><affiliation wicri:level="3"><inist:fA14 i1="11"><s1>Department of Molecular Genetics and Department of Chemotherapy, National Institute of Oncology</s1><s2>Budapest</s2><s3>HUN</s3><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Hongrie</country><placeName><settlement type="city">Budapest</settlement><region nuts="2">Hongrie centrale</region></placeName></affiliation></author><author><name sortKey="Daly, Peter A" sort="Daly, Peter A" uniqKey="Daly P" first="Peter A." last="Daly">Peter A. Daly</name><affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Department of Medical Oncology, St James's Hospital</s1><s2>Dublin</s2><s3>IRL</s3><sZ>16 aut.</sZ></inist:fA14><country>Irlande (pays)</country><wicri:noRegion>Dublin</wicri:noRegion></affiliation></author><author><name sortKey="Guilford, Parry" sort="Guilford, Parry" uniqKey="Guilford P" first="Parry" last="Guilford">Parry Guilford</name><affiliation wicri:level="1"><inist:fA14 i1="13"><s1>Cancer Genetics Laboratory, University of Otago</s1><s2>Dunedin</s2><s3>NZL</s3><sZ>17 aut.</sZ></inist:fA14><country>Nouvelle-Zélande</country><wicri:noRegion>Dunedin</wicri:noRegion></affiliation></author><author><name sortKey="Fossa, Sophie D" sort="Fossa, Sophie D" uniqKey="Fossa S" first="Sophie D." last="Fossa">Sophie D. Fossa</name></author><author><name sortKey="Heimdal, Ketil" sort="Heimdal, Ketil" uniqKey="Heimdal K" first="Ketil" last="Heimdal">Ketil Heimdal</name></author><author><name sortKey="Liubchenko, Ludmila" sort="Liubchenko, Ludmila" uniqKey="Liubchenko L" first="Ludmila" last="Liubchenko">Ludmila Liubchenko</name></author><author><name sortKey="Tjulandin, Sergei A" sort="Tjulandin, Sergei A" uniqKey="Tjulandin S" first="Sergei A." last="Tjulandin">Sergei A. Tjulandin</name></author><author><name sortKey="Stoll, Hans" sort="Stoll, Hans" uniqKey="Stoll H" first="Hans" last="Stoll">Hans Stoll</name></author><author><name sortKey="Weber, Walter" sort="Weber, Walter" uniqKey="Weber W" first="Walter" last="Weber">Walter Weber</name></author><author><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F." last="Easton">Douglas F. Easton</name></author><author><name sortKey="Dudakia, Darshna" sort="Dudakia, Darshna" uniqKey="Dudakia D" first="Darshna" last="Dudakia">Darshna Dudakia</name></author><author><name sortKey="Huddart, Robert" sort="Huddart, Robert" uniqKey="Huddart R" first="Robert" last="Huddart">Robert Huddart</name></author><author><name sortKey="Stratton, Michael R" sort="Stratton, Michael R" uniqKey="Stratton M" first="Michael R." last="Stratton">Michael R. Stratton</name></author><author><name sortKey="Einhorn, Lawrence" sort="Einhorn, Lawrence" uniqKey="Einhorn L" first="Lawrence" last="Einhorn">Lawrence Einhorn</name></author><author><name sortKey="Korde, Larissa" sort="Korde, Larissa" uniqKey="Korde L" first="Larissa" last="Korde">Larissa Korde</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute</s1><s2>Rockville, MD 20852</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>29 aut.</sZ><sZ>33 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Rockville, MD 20852</wicri:noRegion></affiliation></author><author><name sortKey="Nathanson, Katherine L" sort="Nathanson, Katherine L" uniqKey="Nathanson K" first="Katherine L." last="Nathanson">Katherine L. Nathanson</name></author><author><name sortKey="Bishop, D Timothy" sort="Bishop, D Timothy" uniqKey="Bishop D" first="D. Timothy" last="Bishop">D. Timothy Bishop</name></author><author><name sortKey="Rapley, Elizabeth A" sort="Rapley, Elizabeth A" uniqKey="Rapley E" first="Elizabeth A." last="Rapley">Elizabeth A. Rapley</name></author><author><name sortKey="Greene, Mark H" sort="Greene, Mark H" uniqKey="Greene M" first="Mark H." last="Greene">Mark H. Greene</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute</s1><s2>Rockville, MD 20852</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>29 aut.</sZ><sZ>33 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Rockville, MD 20852</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Urologic oncology</title><title level="j" type="abbreviated">Urol. oncol.</title><idno type="ISSN">1078-1439</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Urologic oncology</title><title level="j" type="abbreviated">Urol. oncol.</title><idno type="ISSN">1078-1439</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cancerology</term><term>Characteristic</term><term>Characteristics</term><term>Epidemiology</term><term>Family study</term><term>Genetic linkage</term><term>Histopathology</term><term>International</term><term>Malignant tumor</term><term>Nephrology</term><term>Testicle</term><term>Testicle cancer</term><term>Testicular germ cell tumor</term><term>Urology</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Cancer du testicule</term><term>International</term><term>Liaison génétique</term><term>Histopathologie</term><term>Etude familiale</term><term>Testicule</term><term>Tumeur maligne</term><term>Epidémiologie</term><term>Caractéristique</term><term>Caractéristiques</term><term>Cancérologie</term><term>Néphrologie</term><term>Urologie</term><term>Tumeur germinale du testicule</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Objectives: Familial aggregation of testicular germ cell tumor (TGCT) has been reported, but it is unclear if familial TGCT represents a unique entity with distinct clinicopathologic characteristics. Here we describe a collection of familial TGCT cases from an international consortium, in an effort to elucidate any clinical characteristics that are specific to this population. Materials and methods: Families with ≥2 cases of TGCT enrolled at 18 of the sites participating in the International Testicular Cancer Linkage Consortium were included. We analyzed clinicopathologic characteristics of 985 cases from 461 families. Results: A majority (88.5%) of families had only 2 cases of TGCT. Men with seminoma (50% of cases) had an older mean age at diagnosis than nonseminoma cases (P = 0.001). Among individuals with a history of cryptorchidism, TGCT was more likely to occur in the ipsilateral testis (κ = 0.65). Cousin pairs appeared to represent a unique group, with younger age at diagnosis and a higher prevalence of cryptorchidism than other families. Conclusions: Clinicopathologic characteristics in these familial TGCT cases were similar to those generally described for nonfamilial cases. However, we observed a unique presentation of familial TGCT among cousin pairs. Additional studies are needed to further explore this observation.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Canada</li><li>Danemark</li><li>France</li><li>Hongrie</li><li>Irlande (pays)</li><li>Nouvelle-Zélande</li><li>République tchèque</li><li>États-Unis</li></country><region><li>Bohême centrale</li><li>District de Cologne</li><li>District de Kassel</li><li>Hesse (Land)</li><li>Hongrie centrale</li><li>Hovedstaden</li><li>Nouvelle-Galles du Sud</li><li>Ontario</li><li>Rhénanie-du-Nord-Westphalie</li></region><settlement><li>Budapest</li><li>Cassel (Hesse)</li><li>Cologne</li><li>Copenhague</li><li>Prague</li><li>Sydney</li><li>Toronto</li></settlement><orgName><li>Université de Toronto</li></orgName></list><tree><noCountry><name sortKey="Bishop, D Timothy" sort="Bishop, D Timothy" uniqKey="Bishop D" first="D. Timothy" last="Bishop">D. Timothy Bishop</name><name sortKey="Dudakia, Darshna" sort="Dudakia, Darshna" uniqKey="Dudakia D" first="Darshna" last="Dudakia">Darshna Dudakia</name><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F." last="Easton">Douglas F. Easton</name><name sortKey="Einhorn, Lawrence" sort="Einhorn, Lawrence" uniqKey="Einhorn L" first="Lawrence" last="Einhorn">Lawrence Einhorn</name><name sortKey="Fossa, Sophie D" sort="Fossa, Sophie D" uniqKey="Fossa S" first="Sophie D." last="Fossa">Sophie D. Fossa</name><name sortKey="Heimdal, Ketil" sort="Heimdal, Ketil" uniqKey="Heimdal K" first="Ketil" last="Heimdal">Ketil Heimdal</name><name sortKey="Huddart, Robert" sort="Huddart, Robert" uniqKey="Huddart R" first="Robert" last="Huddart">Robert Huddart</name><name sortKey="Liubchenko, Ludmila" sort="Liubchenko, Ludmila" uniqKey="Liubchenko L" first="Ludmila" last="Liubchenko">Ludmila Liubchenko</name><name sortKey="Nathanson, Katherine L" sort="Nathanson, Katherine L" uniqKey="Nathanson K" first="Katherine L." last="Nathanson">Katherine L. Nathanson</name><name sortKey="Rapley, Elizabeth A" sort="Rapley, Elizabeth A" uniqKey="Rapley E" first="Elizabeth A." last="Rapley">Elizabeth A. Rapley</name><name sortKey="Stoll, Hans" sort="Stoll, Hans" uniqKey="Stoll H" first="Hans" last="Stoll">Hans Stoll</name><name sortKey="Stratton, Michael R" sort="Stratton, Michael R" uniqKey="Stratton M" first="Michael R." last="Stratton">Michael R. Stratton</name><name sortKey="Tjulandin, Sergei A" sort="Tjulandin, Sergei A" uniqKey="Tjulandin S" first="Sergei A." last="Tjulandin">Sergei A. Tjulandin</name><name sortKey="Weber, Walter" sort="Weber, Walter" uniqKey="Weber W" first="Walter" last="Weber">Walter Weber</name></noCountry><country name="États-Unis"><noRegion><name sortKey="Mai, Phuong L" sort="Mai, Phuong L" uniqKey="Mai P" first="Phuong L." last="Mai">Phuong L. Mai</name></noRegion><name sortKey="Greene, Mark H" sort="Greene, Mark H" uniqKey="Greene M" first="Mark H." last="Greene">Mark H. Greene</name><name sortKey="Korde, Larissa" sort="Korde, Larissa" uniqKey="Korde L" first="Larissa" last="Korde">Larissa Korde</name></country><country name="Australie"><region name="Nouvelle-Galles du Sud"><name sortKey="Friedlander, Michael" sort="Friedlander, Michael" uniqKey="Friedlander M" first="Michael" last="Friedlander">Michael Friedlander</name></region><name sortKey="Phillips, Kelly Anne" sort="Phillips, Kelly Anne" uniqKey="Phillips K" first="Kelly-Anne" last="Phillips">Kelly-Anne Phillips</name><name sortKey="Tucker, Kathy" sort="Tucker, Kathy" uniqKey="Tucker K" first="Kathy" last="Tucker">Kathy Tucker</name></country><country name="Canada"><region name="Ontario"><name sortKey="Hogg, David" sort="Hogg, David" uniqKey="Hogg D" first="David" last="Hogg">David Hogg</name></region><name sortKey="Jewett, Michael A S" sort="Jewett, Michael A S" uniqKey="Jewett M" first="Michael A. S." last="Jewett">Michael A. S. Jewett</name></country><country name="République tchèque"><region name="Bohême centrale"><name sortKey="Lohynska, Radka" sort="Lohynska, Radka" uniqKey="Lohynska R" first="Radka" last="Lohynska">Radka Lohynska</name></region></country><country name="Danemark"><region name="Hovedstaden"><name sortKey="Daugaard, Gedske" sort="Daugaard, Gedske" uniqKey="Daugaard G" first="Gedske" last="Daugaard">Gedske Daugaard</name></region></country><country name="France"><noRegion><name sortKey="Richard, Stephane" sort="Richard, Stephane" uniqKey="Richard S" first="Stéphane" last="Richard">Stéphane Richard</name></noRegion><name sortKey="Bonaiti Pellie, Catherine" sort="Bonaiti Pellie, Catherine" uniqKey="Bonaiti Pellie C" first="Catherine" last="Bonaïti-Pellie">Catherine Bonaïti-Pellie</name></country><country name="Allemagne"><region name="Rhénanie-du-Nord-Westphalie"><name sortKey="Heidenreich, Axel" sort="Heidenreich, Axel" uniqKey="Heidenreich A" first="Axel" last="Heidenreich">Axel Heidenreich</name></region><name sortKey="Albers, Peter" sort="Albers, Peter" uniqKey="Albers P" first="Peter" last="Albers">Peter Albers</name></country><country name="Hongrie"><region name="Hongrie centrale"><name sortKey="Bodrogi, Istvan" sort="Bodrogi, Istvan" uniqKey="Bodrogi I" first="Istvan" last="Bodrogi">Istvan Bodrogi</name></region><name sortKey="Geczi, Lajos" sort="Geczi, Lajos" uniqKey="Geczi L" first="Lajos" last="Geczi">Lajos Geczi</name><name sortKey="Olah, Edith" sort="Olah, Edith" uniqKey="Olah E" first="Edith" last="Olah">Edith Olah</name></country><country name="Irlande (pays)"><noRegion><name sortKey="Daly, Peter A" sort="Daly, Peter A" uniqKey="Daly P" first="Peter A." last="Daly">Peter A. Daly</name></noRegion></country><country name="Nouvelle-Zélande"><noRegion><name sortKey="Guilford, Parry" sort="Guilford, Parry" uniqKey="Guilford P" first="Parry" last="Guilford">Parry Guilford</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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